Overcoming Endosomal Barrier by Amphotericin B-Loaded Dual pH-Responsive PDMA-b-PDPA Micelleplexes for siRNA Delivery

The endosomal barrier is a major bottleneck for the effective intracellular delivery of siRNA by nonviral nanocarriers. Here, we report a novel amphotericin B (AmB)-loaded, dual pH-responsive micelleplex platform for siRNA delivery. Micelles were self-assembled from poly(2-(dimethylamino)ethyl metha...

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Pubblicato in:ACS Nano
Autori principali: Yu, Haijun, Zou, Yonglong, Wang, Yiguang, Huang, Xiaonan, Huang, Gang, Sumer, Baran D., Boothman, David A., Gao, Jinming
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2011
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4797624/
https://ncbi.nlm.nih.gov/pubmed/22011045
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn203503h
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