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A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons
The extracellular aggregation of amyloid β (Aβ) peptides and the intracellular hyperphosphorylation of tau at specific epitopes are pathological hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD). Cdk5 phosphorylates tau at AD-specific phospho-epitopes when it associates w...
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| Autors principals: | , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Nature Publishing Group
2005
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC544899/ https://ncbi.nlm.nih.gov/pubmed/15592431 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600441 |
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