A 24-Residue Peptide (p5), Derived from p35, the Cdk5 Neuronal Activator, Specifically Inhibits Cdk5-p25 Hyperactivity and Tau Hyperphosphorylation

The activity of Cdk5-p35 is tightly regulated in the developing and mature nervous system. Stress-induced cleavage of the activator p35 to p25 and a p10 N-terminal domain induces deregulated Cdk5 hyperactivity and perikaryal aggregations of hyperphosphorylated Tau and neurofilaments, pathogenic hall...

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Bibliographic Details
Main Authors: Zheng, Ya-Li, Amin, Niranjana D., Hu, Ya-Fang, Rudrabhatla, Parvathi, Shukla, Varsha, Kanungo, Jyotshnabala, Kesavapany, Sashi, Grant, Philip, Albers, Wayne, Pant, Harish C.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2962518/
https://ncbi.nlm.nih.gov/pubmed/20720012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.134643
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