A truncated peptide from p35, a Cdk5 activator, prevents Alzheimer's disease phenotypes in model mice

Alzheimer's disease (AD), one of the leading neurodegenerative disorders of older adults, which causes major socioeconomic burdens globally, lacks effective therapeutics without significant side effects. Besides the hallmark pathology of amyloid plaques and neurofibrillary tangles (NFTs), it ha...

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Hlavní autoři: Shukla, Varsha, Zheng, Ya-Li, Mishra, Santosh K., Amin, Niranjana D., Steiner, Joseph, Grant, Philip, Kesavapany, Sashi, Pant, Harish C.
Médium: Artigo
Jazyk:Inglês
Vydáno: Federation of American Societies for Experimental Biology 2013
Témata:
Research Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3528323/
https://ncbi.nlm.nih.gov/pubmed/23038754
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-217497
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