Overexpression of the Cdk5 inhibitory peptide in motor neurons rescue of amyotrophic lateral sclerosis phenotype in a mouse model

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects motor nerve cells in the brain and the spinal cord. Etiological mechanisms underlying the disease remain poorly understood; recent studies suggest that deregulation of p25/Cyclin-dependent kinase 5 (Cdk5) act...

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Publicado en:Hum Mol Genet
Main Authors: BK, Binukumar, Skuntz, Susan, Prochazkova, Michaela, Kesavapany, Sashi, Amin, Niranjana D, Shukla, Varsha, Grant, Philip, Kulkarni, Ashok B, Pant, Harish C
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2019
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General Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6859439/
https://ncbi.nlm.nih.gov/pubmed/31189016
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddz118
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