A Cdk5 inhibitory peptide reduces tau hyperphosphorylation and apoptosis in neurons

The extracellular aggregation of amyloid β (Aβ) peptides and the intracellular hyperphosphorylation of tau at specific epitopes are pathological hallmarks of neurodegenerative diseases such as Alzheimer's disease (AD). Cdk5 phosphorylates tau at AD-specific phospho-epitopes when it associates w...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Zheng, Ya-Li, Kesavapany, Sashi, Gravell, Maneth, Hamilton, Rebecca S, Schubert, Manfred, Amin, Niranjana, Albers, Wayne, Grant, Philip, Pant, Harish C
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2005
Schlagworte:
Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC544899/
https://ncbi.nlm.nih.gov/pubmed/15592431
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.emboj.7600441
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