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Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures
Somatic mutations of pre-mRNA splicing factors recur among patients with myelodysplastic syndromes (MDS) and related malignancies. Although these MDS-relevant mutations alter splicing of a subset of transcripts, the mechanisms by which these single amino acid substitutions change gene expression rem...
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| Publicado no: | Trends Genet |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2017
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5447463/ https://ncbi.nlm.nih.gov/pubmed/28372848 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tig.2017.03.001 |
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