CTCF and cohesin regulate chromatin loop stability with distinct dynamics

Folding of mammalian genomes into spatial domains is critical for gene regulation. The insulator protein CTCF and cohesin control domain location by folding domains into loop structures, which are widely thought to be stable. Combining genomic and biochemical approaches we show that CTCF and cohesin...

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Bibliographic Details
Published in:eLife
Main Authors: Hansen, Anders S, Pustova, Iryna, Cattoglio, Claudia, Tjian, Robert, Darzacq, Xavier
Format: Artigo
Language:Inglês
Published: eLife Sciences Publications, Ltd 2017
Subjects:
Biophysics and Structural Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446243/
https://ncbi.nlm.nih.gov/pubmed/28467304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25776
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