Distinct Classes of Chromatin Loops Revealed by Deletion of an RNA-Binding Region in CTCF

Mammalian genomes are folded into topologically associating domains (TADs), consisting of chromatin loops anchored by CTCF and cohesin. Some loops are cell-type specific. Here we asked whether CTCF loops are established by a universal or locus-specific mechanism. Investigating the molecular determin...

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Bibliographic Details
Published in:Mol Cell
Main Authors: Hansen, Anders S., Hsieh, Tsung-Han S., Cattoglio, Claudia, Pustova, Iryna, Saldaña-Meyer, Ricardo, Reinberg, Danny, Darzacq, Xavier, Tjian, Robert
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7251926/
https://ncbi.nlm.nih.gov/pubmed/31522987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.07.039
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