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CTCF and cohesin regulate chromatin loop stability with distinct dynamics

Folding of mammalian genomes into spatial domains is critical for gene regulation. The insulator protein CTCF and cohesin control domain location by folding domains into loop structures, which are widely thought to be stable. Combining genomic and biochemical approaches we show that CTCF and cohesin...

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Détails bibliographiques
Publié dans:eLife
Auteurs principaux: Hansen, Anders S, Pustova, Iryna, Cattoglio, Claudia, Tjian, Robert, Darzacq, Xavier
Format: Artigo
Langue:Inglês
Publié: eLife Sciences Publications, Ltd 2017
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446243/
https://ncbi.nlm.nih.gov/pubmed/28467304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25776
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