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CTCF and cohesin regulate chromatin loop stability with distinct dynamics
Folding of mammalian genomes into spatial domains is critical for gene regulation. The insulator protein CTCF and cohesin control domain location by folding domains into loop structures, which are widely thought to be stable. Combining genomic and biochemical approaches we show that CTCF and cohesin...
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Publié dans: | eLife |
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Auteurs principaux: | , , , , |
Format: | Artigo |
Langue: | Inglês |
Publié: |
eLife Sciences Publications, Ltd
2017
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Sujets: | |
Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5446243/ https://ncbi.nlm.nih.gov/pubmed/28467304 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.25776 |
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