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Guided nuclear exploration increases CTCF target search efficiency
The enormous size of mammalian genomes means that for a DNA-binding protein, the number of non-specific, off-target sites vastly exceeds the number of specific, cognate sites. How mammalian DNA-binding proteins overcome this challenge to efficiently locate their target sites is not known. Here throu...
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| Published in: | Nat Chem Biol |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7036004/ https://ncbi.nlm.nih.gov/pubmed/31792445 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41589-019-0422-3 |
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