MeCP2 recognizes cytosine methylated tri-nucleotide and di-nucleotide sequences to tune transcription in the mammalian brain

Mutations in the gene encoding the methyl-CG binding protein MeCP2 cause several neurological disorders including Rett syndrome. The di-nucleotide methyl-CG (mCG) is the classical MeCP2 DNA recognition sequence, but additional methylated sequence targets have been reported. Here we show by in vitro...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Lagger, Sabine, Connelly, John C., Schweikert, Gabriele, Webb, Shaun, Selfridge, Jim, Ramsahoye, Bernard H., Yu, Miao, He, Chuan, Sanguinetti, Guido, Sowers, Lawrence C., Walkinshaw, Malcolm D., Bird, Adrian
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2017
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5446194/
https://ncbi.nlm.nih.gov/pubmed/28498846
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1006793
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