Inhibition of p70 S6 kinase (S6K1) activity by A77 1726, the active metabolite of leflunomide, induces autophagy through TAK1-mediated AMPK and JNK activation

mTOR activation suppresses autophagy by phosphorylating ULK1 at S757 and suppressing its enzymatic activity. Here we report that feedback activation of mTOR in the PI-3 kinase pathway by two p70 S6 kinase (S6K1) inhibitors (PF-4708671 and A77 1726, the active metabolite of an immunosuppressive drug...

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Publicado en:Oncotarget
Autores principales: Xu, Xiulong, Sun, §Jing, Song, Ruilong, Doscas, Michelle E., Williamson, Ashley J., Zhou, Jingsong, Sun, Jun, Jiao, Xinan, Liu, Xiufan, Li, Yi
Formato: Artigo
Lenguaje:Inglês
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444754/
https://ncbi.nlm.nih.gov/pubmed/28389629
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.16737
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