Inhibition of p70 S6 Kinase (S6K1) Activity by A77 1726 and Its Effect on Cell Proliferation and Cell Cycle Progress()()

Leflunomide is a novel immunomodulatory drug prescribed for treating rheumatoid arthritis. It inhibits the activity of protein tyrosine kinases and dihydroorotate dehydrogenase, a rate-limiting enzyme in the pyrimidine nucleotide synthesis pathway. Here, we report that A77 1726, the active metabolit...

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Detalhes bibliográficos
Main Authors: Doscas, Michelle E., Williamson, Ashley J., Usha, Lydia, Bogachkov, Yedida, Rao, Geetha S., Xiao, Fei, Wang, Yimin, Ruby, Carl, Kaufman, Howard, Zhou, Jingsong, Williams, James W., Li, Yi, Xu, Xiulong
Formato: Artigo
Idioma:Inglês
Publicado em: Neoplasia Press 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4212247/
https://ncbi.nlm.nih.gov/pubmed/25379019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.08.006
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