The active metabolite of leflunomide, A77 1726, interferes with dendritic cell function

Leflunomide, a potent disease-modifying antirheumatic drug used in the treatment of rheumatoid arthritis (RA), exhibits anti-inflammatory, antiproliferative and immunosuppressive effects. Although most of the beneficial effects of leflunomide have been attributed to its antimetabolite activity, main...

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Bibliographic Details
Main Authors: Kirsch, Bernhard M, Zeyda, Maximilian, Stuhlmeier, Karl, Grisar, Johannes, Smolen, Josef S, Watschinger, Bruno, Stulnig, Thomas M, Hörl, Walter H, Zlabinger, Gerhard J, Säemann, Marcus D
Format: Artigo
Language:Inglês
Published: BioMed Central 2005
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC1174963/
https://ncbi.nlm.nih.gov/pubmed/15899055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1727
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