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Therapeutic drug monitoring of A77 1726, the active metabolite of leflunomide: serum concentrations predict response to treatment in patients with rheumatoid arthritis

Background: Leflunomide is the prodrug of the disease modifying antirheumatic metabolite A77 1726. More than 50% of patients withdraw from leflunomide treatment within one year, mainly because of adverse drug reactions. Therapeutic drug monitoring of A77 1726 may be useful in predicting the efficacy...

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書誌詳細
主要な著者: van Roon, E N, Jansen, T, van de Laar, M A F J, Janssen, M, Yska, J, Keuper, R, Houtman, P, Brouwers, J
フォーマット: Artigo
言語:Inglês
出版事項: 2005
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC1755436/
https://ncbi.nlm.nih.gov/pubmed/15345501
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1136/ard.2004.025205
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