Suppressive effect of leflunomide metabolite (A77 1726) on metalloproteinase production in IL-1β stimulated rheumatoid synovial fibroblasts

Leflunomide, an isoxazol derivative structurally unrelated to other immunomodulatory drugs, has proven to be efficacious in the treatment of rheumatoid arthritis (RA). This study was conducted to elucidate the mechanism by which leflunomide mediated antirheumatic effects. We investigated the effects...

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Detalhes bibliográficos
Main Authors: MIGITA, K, MIYASHITA, T, ISHIBASHI, H, MAEDA, Y, NAKAMURA, M, YATSUHASHI, H, IDA, H, KAWAKAMI, A, AOYAGI, T, KAWABE, Y, EGUCHI, K
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Science Inc 2004
Assuntos:
Clinical Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1809130/
https://ncbi.nlm.nih.gov/pubmed/15320915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02555.x
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