Suppressive effect of leflunomide metabolite (A77 1726) on metalloproteinase production in IL-1β stimulated rheumatoid synovial fibroblasts

Leflunomide, an isoxazol derivative structurally unrelated to other immunomodulatory drugs, has proven to be efficacious in the treatment of rheumatoid arthritis (RA). This study was conducted to elucidate the mechanism by which leflunomide mediated antirheumatic effects. We investigated the effects...

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Main Authors: MIGITA, K, MIYASHITA, T, ISHIBASHI, H, MAEDA, Y, NAKAMURA, M, YATSUHASHI, H, IDA, H, KAWAKAMI, A, AOYAGI, T, KAWABE, Y, EGUCHI, K
Formato: Artigo
Idioma:Inglês
Publicado: Blackwell Science Inc 2004
Assuntos:
Clinical Studies
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1809130/
https://ncbi.nlm.nih.gov/pubmed/15320915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2249.2004.02555.x
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