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The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes

Leflunomide is an immunomodulatory agent used for the treatment of rheumatoid arthritis. In this study, we investigated the effect of A77 1726 – the active metabolite of leflunomide – on the production of IL-1 receptor antagonist (IL-1Ra) by human synovial fibroblasts and articular chondrocytes. Cel...

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Detalhes bibliográficos
Main Authors: Palmer, Gaby, Burger, Danielle, Mezin, Françoise, Magne, David, Gabay, Cem, Dayer, Jean-Michel, Guerne, Pierre-André
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC416438/
https://ncbi.nlm.nih.gov/pubmed/15142263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1157
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