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The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes

Leflunomide is an immunomodulatory agent used for the treatment of rheumatoid arthritis. In this study, we investigated the effect of A77 1726 – the active metabolite of leflunomide – on the production of IL-1 receptor antagonist (IL-1Ra) by human synovial fibroblasts and articular chondrocytes. Cel...

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Библиографические подробности
Главные авторы: Palmer, Gaby, Burger, Danielle, Mezin, Françoise, Magne, David, Gabay, Cem, Dayer, Jean-Michel, Guerne, Pierre-André
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2004
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC416438/
https://ncbi.nlm.nih.gov/pubmed/15142263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1157
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