The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes

Leflunomide is an immunomodulatory agent used for the treatment of rheumatoid arthritis. In this study, we investigated the effect of A77 1726 – the active metabolite of leflunomide – on the production of IL-1 receptor antagonist (IL-1Ra) by human synovial fibroblasts and articular chondrocytes. Cel...

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Hlavní autoři: Palmer, Gaby, Burger, Danielle, Mezin, Françoise, Magne, David, Gabay, Cem, Dayer, Jean-Michel, Guerne, Pierre-André
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2004
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC416438/
https://ncbi.nlm.nih.gov/pubmed/15142263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1157
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