The active metabolite of leflunomide, A77 1726, increases the production of IL-1 receptor antagonist in human synovial fibroblasts and articular chondrocytes

Leflunomide is an immunomodulatory agent used for the treatment of rheumatoid arthritis. In this study, we investigated the effect of A77 1726 – the active metabolite of leflunomide – on the production of IL-1 receptor antagonist (IL-1Ra) by human synovial fibroblasts and articular chondrocytes. Cel...

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Autores principales: Palmer, Gaby, Burger, Danielle, Mezin, Françoise, Magne, David, Gabay, Cem, Dayer, Jean-Michel, Guerne, Pierre-André
Formato: Artigo
Lenguaje:Inglês
Publicado: BioMed Central 2004
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC416438/
https://ncbi.nlm.nih.gov/pubmed/15142263
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/ar1157
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