Purification of human dihydro-orotate dehydrogenase and its inhibition by A77 1726, the active metabolite of leflunomide.

Leflunomide is currently in phase-III clinical trials for the treatment of rheumatoid arthritis. In this study, we have focused our efforts on the study of the mechanism of action of the active metabolite of leflunomide, A77 1726, in cells and tissue of human origin. The human high-affinity binding...

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Detalhes bibliográficos
Main Authors: Bruneau, J M, Yea, C M, Spinella-Jaegle, S, Fudali, C, Woodward, K, Robson, P A, Sautès, C, Westwood, R, Kuo, E A, Williamson, R A, Ruuth, E
Formato: Artigo
Idioma:Inglês
Publicado em: 1998
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1219871/
https://ncbi.nlm.nih.gov/pubmed/9820804
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