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Inhibition of p70 S6 Kinase (S6K1) Activity by A77 1726 and Its Effect on Cell Proliferation and Cell Cycle Progress()()

Leflunomide is a novel immunomodulatory drug prescribed for treating rheumatoid arthritis. It inhibits the activity of protein tyrosine kinases and dihydroorotate dehydrogenase, a rate-limiting enzyme in the pyrimidine nucleotide synthesis pathway. Here, we report that A77 1726, the active metabolit...

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Detaylı Bibliyografya
Asıl Yazarlar: Doscas, Michelle E., Williamson, Ashley J., Usha, Lydia, Bogachkov, Yedida, Rao, Geetha S., Xiao, Fei, Wang, Yimin, Ruby, Carl, Kaufman, Howard, Zhou, Jingsong, Williams, James W., Li, Yi, Xu, Xiulong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Neoplasia Press 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4212247/
https://ncbi.nlm.nih.gov/pubmed/25379019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2014.08.006
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