Inhibition of p70 S6 kinase activity by A77 1726 induces autophagy and enhances the degradation of superoxide dismutase 1 (SOD1) protein aggregates

Autophagy plays a central role in degrading misfolded proteins such as mutated superoxide dismutase 1 (SOD1), which forms aggregates in motor neurons and is involved in the pathogenesis of amyotrophic lateral sclerosis (ALS). Autophagy is activated when UNC-51-like kinase 1 (ULK1) is phosphorylated...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Sun, Jing, Mu, Yarong, Jiang, Yuanyuan, Song, Ruilong, Yi, Jianxin, Zhou, Jingsong, Sun, Jun, Jiao, Xinan, Prinz, Richard A., Li, Yi, Xu, Xiulong
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
Assuntos:
Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5851998/
https://ncbi.nlm.nih.gov/pubmed/29540819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-018-0441-0
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados