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Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance

HIV-1 reverse transcriptase (RT) is targeted by multiple drugs. RT mutations that confer resistance to nucleoside RT inhibitors (NRTIs) emerge during clinical use. Q151M and four associated mutations, A62V, V75I, F77L, and F116Y, were detected in patients failing therapies with dideoxynucleosides (d...

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Bibliografiske detaljer
Udgivet i:Antimicrob Agents Chemother
Main Authors: Das, Kalyan, Martinez, Sergio E., Arnold, Eddy
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2017
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444136/
https://ncbi.nlm.nih.gov/pubmed/28396546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00224-17
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