Mutation V111I in HIV-2 Reverse Transcriptase Increases the Fitness of the Nucleoside Analogue-Resistant K65R and Q151M Viruses

Infection with HIV-2 can ultimately lead to AIDS, although disease progression is much slower than with HIV-1. HIV-2 patients are mostly treated with a combination of nucleoside reverse transcriptase (RT) inhibitors (NRTIs) and protease inhibitors designed for HIV-1. Many studies have described the...

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Detalhes bibliográficos
Publicado no:J Virol
Principais autores: Deuzing, Ilona P., Charpentier, Charlotte, Wright, David W., Matheron, Sophie, Paton, Jack, Frentz, Dineke, van de Vijver, David A., Coveney, Peter V., Descamps, Diane, Boucher, Charles A. B., Beerens, Nancy
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4301157/
https://ncbi.nlm.nih.gov/pubmed/25355888
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02259-14
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