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Structural Insights into HIV Reverse Transcriptase Mutations Q151M and Q151M Complex That Confer Multinucleoside Drug Resistance

HIV-1 reverse transcriptase (RT) is targeted by multiple drugs. RT mutations that confer resistance to nucleoside RT inhibitors (NRTIs) emerge during clinical use. Q151M and four associated mutations, A62V, V75I, F77L, and F116Y, were detected in patients failing therapies with dideoxynucleosides (d...

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書誌詳細
出版年:Antimicrob Agents Chemother
主要な著者: Das, Kalyan, Martinez, Sergio E., Arnold, Eddy
フォーマット: Artigo
言語:Inglês
出版事項: American Society for Microbiology 2017
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC5444136/
https://ncbi.nlm.nih.gov/pubmed/28396546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00224-17
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