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Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene.

Collagenase (matrix metalloproteinase 1) cleaves type I, II, and III collagen helices at a specific site between Gly-Ile or Gly-Leu bonds (residues 775 and 776, P1-P1'). To understand the mechanism of collagen processing, mutations around the cleavage site have been introduced into the cloned murine...

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Udgivet i:Proc Natl Acad Sci U S A
Principais autores: Wu, H, Byrne, M H, Stacey, A, Goldring, M B, Birkhead, J R, Jaenisch, R, Krane, S M
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 1990
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54434/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2165607/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.15.5888
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