Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene.

Collagenase (matrix metalloproteinase 1) cleaves type I, II, and III collagen helices at a specific site between Gly-Ile or Gly-Leu bonds (residues 775 and 776, P1-P1'). To understand the mechanism of collagen processing, mutations around the cleavage site have been introduced into the cloned m...

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Bibliografiska uppgifter
Huvudupphovsmän: Wu, H, Byrne, M H, Stacey, A, Goldring, M B, Birkhead, J R, Jaenisch, R, Krane, S M
Materialtyp: Artigo
Språk:Inglês
Publicerad: 1990
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC54434/
https://ncbi.nlm.nih.gov/pubmed/2165607
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