Introduction of the human pro alpha 1(I) collagen gene into pro alpha 1(I)-deficient Mov-13 mouse cells leads to formation of functional mouse-human hybrid type I collagen.
The Mov-13 mouse strain carries a retroviral insertion in the pro alpha 1(I) collagen gene that prevents transcription of the gene. Cell lines derived from homozygous embryos do not express type I collagen although normal amounts of pro alpha 2 mRNA are synthesized. We have introduced genomic clones...
Na minha lista:
| Udgivet i: | Proc Natl Acad Sci U S A |
|---|---|
| Principais autores: | , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
National Academy of Sciences
1987
|
| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304296/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3468512/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.3.764 |
| Tags: |
Ingen Tags, Vær først til at tagge denne postø!
|