Introduction of the human pro alpha 1(I) collagen gene into pro alpha 1(I)-deficient Mov-13 mouse cells leads to formation of functional mouse-human hybrid type I collagen.

The Mov-13 mouse strain carries a retroviral insertion in the pro alpha 1(I) collagen gene that prevents transcription of the gene. Cell lines derived from homozygous embryos do not express type I collagen although normal amounts of pro alpha 2 mRNA are synthesized. We have introduced genomic clones...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Schnieke, A, Dziadek, M, Bateman, J, Mascara, T, Harbers, K, Gelinas, R, Jaenisch, R
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 1987
Assuntos:
Research Article
Acceso en liña:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC304296/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/3468512/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.84.3.764
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