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Introduction of the human pro alpha 1(I) collagen gene into pro alpha 1(I)-deficient Mov-13 mouse cells leads to formation of functional mouse-human hybrid type I collagen.

The Mov-13 mouse strain carries a retroviral insertion in the pro alpha 1(I) collagen gene that prevents transcription of the gene. Cell lines derived from homozygous embryos do not express type I collagen although normal amounts of pro alpha 2 mRNA are synthesized. We have introduced genomic clones...

詳細記述

保存先:
書誌詳細
主要な著者: Schnieke, A, Dziadek, M, Bateman, J, Mascara, T, Harbers, K, Gelinas, R, Jaenisch, R
フォーマット: Artigo
言語:Inglês
出版事項: 1987
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC304296/
https://ncbi.nlm.nih.gov/pubmed/3468512
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