Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice.

The Mov13 mouse strain carries a mutation in the alpha 1(I) procollagen gene which is due to the insertion of a Moloney murine leukemia provirus into the first intron. This insertion results in the de novo methylation of the provirus and flanking DNA, the alteration of chromatin structure, and the t...

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Bibliographic Details
Main Authors: Barker, D D, Wu, H, Hartung, S, Breindl, M, Jaenisch, R
Format: Artigo
Language:Inglês
Published: 1991
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Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC361539/
https://ncbi.nlm.nih.gov/pubmed/1922037
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