Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene.

Collagenase (matrix metalloproteinase 1) cleaves type I, II, and III collagen helices at a specific site between Gly-Ile or Gly-Leu bonds (residues 775 and 776, P1-P1'). To understand the mechanism of collagen processing, mutations around the cleavage site have been introduced into the cloned murine...

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Publicat a:	Proc Natl Acad Sci U S A
Autors principals:	Wu, H, Byrne, M H, Stacey, A, Goldring, M B, Birkhead, J R, Jaenisch, R, Krane, S M
Format:	Artigo
Idioma:	Inglês
Publicat:	National Academy of Sciences 1990
Matèries:	Research Article
Accés en línia:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC54434/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2165607/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.87.15.5888
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