The Predominant Mechanism by Which Ribavirin Exerts Its Antiviral Activity In Vitro against Flaviviruses and Paramyxoviruses Is Mediated by Inhibition of IMP Dehydrogenase

It is not yet clear to what extent depletion of intracellular GTP pools contributes to the antiviral activity of ribavirin. Therefore, the antiviral activities of (i) ribavirin, (ii) its 5-ethynyl analogue, 5-ethynyl-1-β-d-ribofuranosylimidazole-4-carboxamide (EICAR), and (iii) mycophenolic acid (MP...

Täydet tiedot

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Bibliografiset tiedot
Päätekijät: Leyssen, Pieter, Balzarini, Jan, De Clercq, Erik, Neyts, Johan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Society for Microbiology 2005
Aiheet:
Vaccines and Antiviral Agents
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC544097/
https://ncbi.nlm.nih.gov/pubmed/15650220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.3.1943-1947.2005
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