The Predominant Mechanism by Which Ribavirin Exerts Its Antiviral Activity In Vitro against Flaviviruses and Paramyxoviruses Is Mediated by Inhibition of IMP Dehydrogenase

It is not yet clear to what extent depletion of intracellular GTP pools contributes to the antiviral activity of ribavirin. Therefore, the antiviral activities of (i) ribavirin, (ii) its 5-ethynyl analogue, 5-ethynyl-1-β-d-ribofuranosylimidazole-4-carboxamide (EICAR), and (iii) mycophenolic acid (MP...

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Detalhes bibliográficos
Main Authors: Leyssen, Pieter, Balzarini, Jan, De Clercq, Erik, Neyts, Johan
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2005
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC544097/
https://ncbi.nlm.nih.gov/pubmed/15650220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.3.1943-1947.2005
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