The Predominant Mechanism by Which Ribavirin Exerts Its Antiviral Activity In Vitro against Flaviviruses and Paramyxoviruses Is Mediated by Inhibition of IMP Dehydrogenase

It is not yet clear to what extent depletion of intracellular GTP pools contributes to the antiviral activity of ribavirin. Therefore, the antiviral activities of (i) ribavirin, (ii) its 5-ethynyl analogue, 5-ethynyl-1-β-d-ribofuranosylimidazole-4-carboxamide (EICAR), and (iii) mycophenolic acid (MP...

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Dades bibliogràfiques
Autors principals: Leyssen, Pieter, Balzarini, Jan, De Clercq, Erik, Neyts, Johan
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2005
Matèries:
Vaccines and Antiviral Agents
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC544097/
https://ncbi.nlm.nih.gov/pubmed/15650220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.3.1943-1947.2005
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