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The Predominant Mechanism by Which Ribavirin Exerts Its Antiviral Activity In Vitro against Flaviviruses and Paramyxoviruses Is Mediated by Inhibition of IMP Dehydrogenase

It is not yet clear to what extent depletion of intracellular GTP pools contributes to the antiviral activity of ribavirin. Therefore, the antiviral activities of (i) ribavirin, (ii) its 5-ethynyl analogue, 5-ethynyl-1-β-d-ribofuranosylimidazole-4-carboxamide (EICAR), and (iii) mycophenolic acid (MP...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Κύριοι συγγραφείς: Leyssen, Pieter, Balzarini, Jan, De Clercq, Erik, Neyts, Johan
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: American Society for Microbiology 2005
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC544097/
https://ncbi.nlm.nih.gov/pubmed/15650220
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.79.3.1943-1947.2005
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