Stromal PDGFR-α Activation Enhances Matrix Stiffness, Impedes Mammary Ductal Development, and Accelerates Tumor Growth

The extracellular matrix (ECM) is critical for mammary ductal development and differentiation, but how mammary fibroblasts regulate ECM remodeling remains to be elucidated. Herein, we used a mouse genetic model to activate platelet derived growth factor receptor-alpha (PDGFRα) specifically in the st...

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Veröffentlicht in:Neoplasia
Hauptverfasser: Hammer, Anisha M., Sizemore, Gina M., Shukla, Vasudha C., Avendano, Alex, Sizemore, Steven T., Chang, Jonathan J., Kladney, Raleigh D., Cuitiño, Maria C., Thies, Katie A., Verfurth, Quinn, Chakravarti, Arnab, Yee, Lisa D., Leone, Gustavo, Song, Jonathan W., Ghadiali, Samir N., Ostrowski, Michael C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Neoplasia Press 2017
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Original article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5440288/
https://ncbi.nlm.nih.gov/pubmed/28501760
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neo.2017.04.004
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