PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3

Glioblastoma (GBM) is the most lethal type of human brain cancer, where deletions and mutations in the tumour suppressor gene PTEN (phosphatase and tensin homolog) are frequent events and are associated with therapeutic resistance. Herein, we report a novel chromatin-associated function of PTEN in c...

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Udgivet i:Nat Commun
Main Authors: Benitez, Jorge A., Ma, Jianhui, D’Antonio, Matteo, Boyer, Antonia, Camargo, Maria Fernanda, Zanca, Ciro, Kelly, Stephen, Khodadadi-Jamayran, Alireza, Jameson, Nathan M., Andersen, Michael, Miletic, Hrvoje, Saberi, Shahram, Frazer, Kelly A., Cavenee, Webster K., Furnari, Frank B.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437297/
https://ncbi.nlm.nih.gov/pubmed/28497778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms15223
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