DDIS-24. PROTEASOME INHIBITION IS A TARGETED THERAPY FOR PTEN-DEFICIENT GLIOBLASTOMAS

One of the most common genetic alterations in glioblastoma (30–40%) occurs in the PTEN (phosphatase and tensin homolog) tumor suppressor gene, where loss of function has been mechanistically linked to increased tumor cell invasion, and to a lack of radio- and chemo-therapy response. To identify new...

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Pubblicato in:Neuro Oncol
Autori principali: Benitez, Jorge, Finlay, Darren, Ma, Jianhui, Koga, Tomoyuki, Vuori, Kristiina, Furnari, Frank
Natura: Artigo
Lingua:Inglês
Pubblicazione: Oxford University Press 2018
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Abstracts
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6216315/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noy148.303
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