Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels

The concentration of free cytosolic Ca(2+) and the voltage across the plasma membrane are major determinants of cell function. Ca(2+)-permeable non-selective cationic channels are known to regulate these parameters, but understanding of these channels remains inadequate. Here we focus on transient r...

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Bibliografske podrobnosti
izdano v:J Biol Chem
Main Authors: Rubaiy, Hussein N., Ludlow, Melanie J., Henrot, Matthias, Gaunt, Hannah J., Miteva, Katarina, Cheung, Sin Ying, Tanahashi, Yasuyuki, Hamzah, Nurasyikin, Musialowski, Katie E., Blythe, Nicola M., Appleby, Hollie L., Bailey, Marc A., McKeown, Lynn, Taylor, Roger, Foster, Richard, Waldmann, Herbert, Nussbaumer, Peter, Christmann, Mathias, Bon, Robin S., Muraki, Katsuhiko, Beech, David J.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2017
Teme:
Molecular Biophysics
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437225/
https://ncbi.nlm.nih.gov/pubmed/28325835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773556
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