(–)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels

Current therapies for common types of cancer such as renal cell cancer often are ineffective and unspecific, and novel pharmacological targets and approaches are in high demand. Here we show the unexpected possibility for rapid and selective killing of renal cancer cells through activation of calciu...

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Bibliografiske detaljer
Udgivet i:Angew Chem Int Ed Engl
Main Authors: Akbulut, Yasemin, Gaunt, Hannah J, Muraki, Katsuhiko, Ludlow, Melanie J, Amer, Mohamed S, Bruns, Alexander, Vasudev, Naveen S, Radtke, Lea, Willot, Matthieu, Hahn, Sven, Seitz, Tobias, Ziegler, Slava, Christmann, Mathias, Beech, David J, Waldmann, Herbert
Format: Artigo
Sprog:Inglês
Udgivet: 2015
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116557/
https://ncbi.nlm.nih.gov/pubmed/25707820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201411511
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