(–)-Englerin A is a potent and selective activator of TRPC4 and TRPC5 calcium channels

Current therapies for common types of cancer such as renal cell cancer often are ineffective and unspecific, and novel pharmacological targets and approaches are in high demand. Here we show the unexpected possibility for rapid and selective killing of renal cancer cells through activation of calciu...

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Detalhes bibliográficos
Publicado no:Angew Chem Int Ed Engl
Main Authors: Akbulut, Yasemin, Gaunt, Hannah J, Muraki, Katsuhiko, Ludlow, Melanie J, Amer, Mohamed S, Bruns, Alexander, Vasudev, Naveen S, Radtke, Lea, Willot, Matthieu, Hahn, Sven, Seitz, Tobias, Ziegler, Slava, Christmann, Mathias, Beech, David J, Waldmann, Herbert
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7116557/
https://ncbi.nlm.nih.gov/pubmed/25707820
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201411511
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