Na(+) entry through heteromeric TRPC4/C1 channels mediates (−)Englerin A-induced cytotoxicity in synovial sarcoma cells

The sesquiterpene (−)Englerin A (EA) is an organic compound from the plant Phyllanthus engleri which acts via heteromeric TRPC4/C1 channels to cause cytotoxicity in some types of cancer cell but not normal cells. Here we identified selective cytotoxicity of EA in human synovial sarcoma cells (SW982...

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Vydáno v:Sci Rep
Hlavní autoři: Muraki, Katsuhiko, Ohnishi, Kaori, Takezawa, Akiho, Suzuki, Hiroka, Hatano, Noriyuki, Muraki, Yukiko, Hamzah, Nurasyikin, Foster, Richard, Waldmann, Herbert, Nussbaumer, Peter, Christmann, Mathias, Bon, Robin S., Beech, David J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5717101/
https://ncbi.nlm.nih.gov/pubmed/29209034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-17303-3
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