Picomolar, selective, and subtype-specific small-molecule inhibition of TRPC1/4/5 channels

The concentration of free cytosolic Ca(2+) and the voltage across the plasma membrane are major determinants of cell function. Ca(2+)-permeable non-selective cationic channels are known to regulate these parameters, but understanding of these channels remains inadequate. Here we focus on transient r...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Rubaiy, Hussein N., Ludlow, Melanie J., Henrot, Matthias, Gaunt, Hannah J., Miteva, Katarina, Cheung, Sin Ying, Tanahashi, Yasuyuki, Hamzah, Nurasyikin, Musialowski, Katie E., Blythe, Nicola M., Appleby, Hollie L., Bailey, Marc A., McKeown, Lynn, Taylor, Roger, Foster, Richard, Waldmann, Herbert, Nussbaumer, Peter, Christmann, Mathias, Bon, Robin S., Muraki, Katsuhiko, Beech, David J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Molecular Biophysics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5437225/
https://ncbi.nlm.nih.gov/pubmed/28325835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.773556
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