SUMOylation and calcium control syntaxin-1A and secretagogin sequestration by tomosyn to regulate insulin exocytosis in human ß cells

Insulin secretion from pancreatic ß cells is a multistep process that requires the coordination of exocytotic proteins that integrate diverse signals. These include signals derived from metabolic control of post-translational SUMOylation and depolarization-induced rises in intracellular Ca(2+). Here...

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Опубликовано в: :Sci Rep
Главные авторы: Ferdaoussi, Mourad, Fu, Jianyang, Dai, Xiaoqing, Manning Fox, Jocelyn E., Suzuki, Kunimasa, Smith, Nancy, Plummer, Gregory, MacDonald, Patrick E.
Формат: Artigo
Язык:Inglês
Опубликовано: Nature Publishing Group UK 2017
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC5428262/
https://ncbi.nlm.nih.gov/pubmed/28325894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-00344-z
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