Kv2.1 Clustering Contributes to Insulin Exocytosis and Rescues Human β-Cell Dysfunction

Insulin exocytosis is regulated by ion channels that control excitability and Ca(2+) influx. Channels also play an increasingly appreciated role in microdomain structure. In this study, we examine the mechanism by which the voltage-dependent K(+) (Kv) channel Kv2.1 (KCNB1) facilitates depolarization...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Fu, Jianyang, Dai, Xiaoqing, Plummer, Gregory, Suzuki, Kunimasa, Bautista, Austin, Githaka, John M., Senior, Laura, Jensen, Mette, Greitzer-Antes, Dafna, Manning Fox, Jocelyn E., Gaisano, Herbert Y., Newgard, Christopher B., Touret, Nicolas, MacDonald, Patrick E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2017
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5482075/
https://ncbi.nlm.nih.gov/pubmed/28607108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-1170
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