Time-Resolved Transcriptomics and Constraint-Based Modeling Identify System-Level Metabolic Features and Overexpression Targets to Increase Spiramycin Production in Streptomyces ambofaciens

In this study we have applied an integrated system biology approach to characterize the metabolic landscape of Streptomyces ambofaciens and to identify a list of potential metabolic engineering targets for the overproduction of the secondary metabolites in this microorganism. We focused on an often...

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Enregistré dans:
Détails bibliographiques
Publié dans:Front Microbiol
Auteurs principaux: Fondi, Marco, Pinatel, Eva, Talà, Adelfia, Damiano, Fabrizio, Consolandi, Clarissa, Mattorre, Benedetta, Fico, Daniela, Testini, Mariangela, De Benedetto, Giuseppe E., Siculella, Luisa, De Bellis, Gianluca, Alifano, Pietro, Peano, Clelia
Format: Artigo
Langue:Inglês
Publié: Frontiers Media S.A. 2017
Sujets:
Microbiology
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427115/
https://ncbi.nlm.nih.gov/pubmed/28553270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.00835
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