Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis.

Several cosmid clones from Streptomyces ambofaciens containing the spiramycin resistance gene srmB were introduced into S. fradiae PM73, a mutant defective in tylosin synthesis, resulting in tylosin synthesis. The DNA responsible for this complementation was localized to a 10.5-kilobase EcoRI fragme...

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Pubblicato in:	J Bacteriol
Autori principali:	Richardson, M A, Kuhstoss, S, Huber, M L, Ford, L, Godfrey, O, Turner, J R, Rao, R N
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 1990
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC213357/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2193916/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.172.7.3790-3798.1990
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