Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis.

Several cosmid clones from Streptomyces ambofaciens containing the spiramycin resistance gene srmB were introduced into S. fradiae PM73, a mutant defective in tylosin synthesis, resulting in tylosin synthesis. The DNA responsible for this complementation was localized to a 10.5-kilobase EcoRI fragme...

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Main Authors: Richardson, M A, Kuhstoss, S, Huber, M L, Ford, L, Godfrey, O, Turner, J R, Rao, R N
格式: Artigo
語言:Inglês
出版: 1990
主題:
Research Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC213357/
https://ncbi.nlm.nih.gov/pubmed/2193916
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