Cloning of spiramycin biosynthetic genes and their use in constructing Streptomyces ambofaciens mutants defective in spiramycin biosynthesis.

Several cosmid clones from Streptomyces ambofaciens containing the spiramycin resistance gene srmB were introduced into S. fradiae PM73, a mutant defective in tylosin synthesis, resulting in tylosin synthesis. The DNA responsible for this complementation was localized to a 10.5-kilobase EcoRI fragme...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Richardson, M A, Kuhstoss, S, Huber, M L, Ford, L, Godfrey, O, Turner, J R, Rao, R N
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1990
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC213357/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/2193916/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.172.7.3790-3798.1990
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