Time-Resolved Transcriptomics and Constraint-Based Modeling Identify System-Level Metabolic Features and Overexpression Targets to Increase Spiramycin Production in Streptomyces ambofaciens

In this study we have applied an integrated system biology approach to characterize the metabolic landscape of Streptomyces ambofaciens and to identify a list of potential metabolic engineering targets for the overproduction of the secondary metabolites in this microorganism. We focused on an often...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Front Microbiol
Autori principali: Fondi, Marco, Pinatel, Eva, Talà, Adelfia, Damiano, Fabrizio, Consolandi, Clarissa, Mattorre, Benedetta, Fico, Daniela, Testini, Mariangela, De Benedetto, Giuseppe E., Siculella, Luisa, De Bellis, Gianluca, Alifano, Pietro, Peano, Clelia
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2017
Soggetti:
Microbiology
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5427115/
https://ncbi.nlm.nih.gov/pubmed/28553270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2017.00835
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