Selective Inhibition of Orexin-2 Receptors Prevents Stress-Induced ACTH Release in Mice

Orexins peptides exert a prominent role in arousal-related processes including stress responding, by activating orexin-1 (OX1R) and orexin-2 (OX2R) receptors located widely throughout the brain. Stress or orexin administration stimulates hyperarousal, adrenocorticotropic hormone (ACTH) and corticost...

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Vydáno v:Front Behav Neurosci
Hlavní autoři: Yun, Sujin, Wennerholm, Michelle, Shelton, Jonathan E., Bonaventure, Pascal, Letavic, Michael A., Shireman, Brock T., Lovenberg, Timothy W., Dugovic, Christine
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2017
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5420581/
https://ncbi.nlm.nih.gov/pubmed/28533747
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnbeh.2017.00083
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