A Selective Orexin-1 Receptor Antagonist Attenuates Stress-Induced Hyperarousal without Hypnotic Effects

Orexins (OXs) are peptides produced by perifornical (PeF) and lateral hypothalamic neurons that exert a prominent role in arousal-related processes, including stress. A critical role for the orexin-1 receptor (OX1R) in complex emotional behavior is emerging, such as overactivation of the OX1R pathwa...

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Detalhes bibliográficos
Publicado no:J Pharmacol Exp Ther
Main Authors: Bonaventure, Pascal, Yun, Sujin, Johnson, Philip L., Shekhar, Anantha, Fitz, Stephanie D., Shireman, Brock T., Lebold, Terry P., Nepomuceno, Diane, Lord, Brian, Wennerholm, Michelle, Shelton, Jonathan, Carruthers, Nicholas, Lovenberg, Timothy, Dugovic, Christine
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Pharmacology and Experimental Therapeutics 2015
Assuntos:
Drug Discovery and Translational Medicine
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4352589/
https://ncbi.nlm.nih.gov/pubmed/25583879
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.114.220392
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